Sanare Lab – Fenbendazole Reduces Radiation Sensitivity in EMT6 Mammary Tumor Cells
We studied the effect of fenbendazole, a widely used antihelminth with mechanisms that overlap with those of hypoxia-selective nitroheterocyclic cytotoxins and radiosensitizers, on radiation sensitivity in EMT6 mammary tumor cells in vitro and in mouse tumors. 2- and 24-h treatments with fenbendazole reduced yield-corrected surviving fractions but did not alter the radiation dose-response curves. Antihelminthic […]
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