Fenbendazole works with Berberine to destroy cancer cells by limiting their ability to take up glucose. It has also been shown to boost p53 production, which helps cancer patients survive.
During facility treatment for pinworms, the anthelmintic fenbendazole failed to inhibit the growth of an established human lymphoma xenograft in SCID mice. The study diet was a sterilizable diet supplemented with additional vitamins to compensate for losses during dietary sterilization.
Fenbendazole
Fenbendazole is an anthelmintic used for rodent pinworms. It is also a popular treatment for cancer. This anthelmintic destroys microtubules that sustain the structure of cancer cells and helps kill them by inhibiting their ability to process sugar. It also boosts the production of p53, a gene that prevents cancer cell proliferation. This deworming medication has gained attention following some fenbendazole cancer success stories.
During an 8-wk facility treatment for Aspiculuris tetraptera pinworms at our institution, human lymphoma xenografts failed to grow in C.B-17/Icr-Prkdcscid/Crl (SCID) mice. This well established xenograft model normally results in 80% to 100% tumor growth within 21 d. Initial complete blood counts showed low white cell count with a paucity of lymphocytes in control and test groups. However, the terminal total white cell and neutrophil counts in the fenbendazole-plus vitamin group were significantly (P = 0.001 and P = 0.04) lower than those in the control group. This difference was not attributed to differences in the dietary preparation as the study diets were sterilized using a commercial irradiator and supplemental vitamins were added to compensate for losses during autoclaving.
Berberine
Berberine is an alkaloid extracted from several plants with a long history of use in Chinese medicine. It acts as an antidiabetic agent by increasing insulin secretion and inhibiting glucose absorption in the gut. It also reduces blood lipids and cholesterol levels. It has been shown to suppress cancer growth and induce apoptosis in cells. It also regulates MAPK signaling pathways in human colon cancer cells and hepatoma cells. This modulation is dose- and time-dependent and involves the downregulation of 33 genes involved in cell cycle regulation and differentiation.
Another benefit of berberine is that it can enhance the metabolic homoeostasis of the host through its impact on gut microbiota composition. In particular, it can increase the proportion of bacteria that produce short-chain fatty acids and bile acid synthesis. It can also affect microbial metabolism and the production of interleukins, inflammatory mediators, and enzymes that regulate lipid metabolism and cholesterol levels. This effect is related to its antidiabetic effects and may also be responsible for its anticancer activity.
CBD
CBD is an all-natural compound that has many potential health benefits. It can relieve pain and reduce anxiety, among other things. It can also help treat seizures and nausea. However, it is important to note that CBD interacts with certain medications, so consult your doctor before using it. This includes benzodiazepine sedatives like Klonopin (clonazepam) and Ativan (lorazepam), immune-suppressants such as Sandimmune (cyclosporine), and opioid painkillers like morphine. CBD can increase the effects of these medications and may cause drowsiness or other side effects.
During an 8-wk facility treatment with fenbendazole to control pinworm infestation at our institution, human lymphoma xenografts failed to grow in C.B-17/Icr-Prkdcscid/Crl SCID mice, a well-established model that normally results in 80% to 100% successful tumor growth within 21 d. This failure to grow is likely attributable to low vitamin concentrations in the study diet used for this observation, which was near expiration and had lower vitamin concentrations than that of the irradiated diet used during initial observations.
THC
THC is the psychoactive component of cannabis (marijuana) and can cause a variety of effects, including anxiety, paranoia, dry mouth, and nausea. It acts by binding to CB1 and CB2 receptors in the brain, which trigger a series of downstream signaling pathways involving cyclic AMP, Ca2+ ions, and dopamine. These are associated with cognitive, pain, reward, and movement functions.
It is also thought to interact with endogenous ligands such as anandamides and can influence GABAergic, opioid, and dopaminergic systems. It has been shown to have anti-emetic properties and is used in chemotherapy to reduce the risk of nausea and vomiting.
Although THC is currently illegal in most states, it is a useful treatment for certain types of cancer-related nausea. This activity will discuss indications, contraindications, off-label use, and pharmacodynamics of two FDA-approved synthetic THC formulations: nabilone and dronabinol. The goal of this activity is to promote interprofessional collaboration for improved patient outcomes in patients receiving THC products for medically approved indications.sanare lab fenbendazole